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Epub 2013 Jan 8
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These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML
CAS Number: 917393-39-6
GSK2118436 is sufficient to reduce S6P phosphorylation in A375
WHI-P154 - CAS# 211555-04-3 Catalog No.:M6563-2 Epub 2013 Jan 8WHI P154, CAS No. 211555 04 3, is a JAK3 inhibitor with IC50 = 1. 8 microM. WHI P154 displays no activity at JAK1 or JAK2. WHI P154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro . Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3 K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 microM). Product information CAS Number: 211555 04 3 Molecular