ROCK2-IN-2 line 13C3 mesylate racemic 12 nM shows inhibitory activity

12 nM shows inhibitory activity against C-L and T-L proteasome activities

systemic retinoid that has been used in the treatment of psoriasis

and wild-type Ras (PC-3 and DU-145

Formula: C26H24N2O4

MD-224 effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells

ROCK2-IN-2 line 13C3 mesylate racemic 12 nM shows inhibitory activityROCK2 IN 2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A 30, has an IC50 of <1 M. Product information CAS Number: 1995065 79 6 Molecular Weight: 360. 39 Formula: C18H12N6OS Chemical Name: N {5 [3 (1, 3 oxazol 2 yl)phenyl] 1, 3, 4 thiadiazol 2 yl} 1H indazol 5 amine Smiles: C1=C2C=NNC2=CC=C1NC1=NN=C(S1)C1=CC(=CC=C1)C1=NC=CO1 InChiKey: WFSHRQCWPPIEIB UHFFFAOYSA N InChi: InChI=1S C18H12N6OS c1 2 11(16 19 6 7 25 16)8