Pay in 4 interest-free payments of $14.50 Learn more
Ships within 48 hours · Estimated delivery Jul 25 - Jul 30
4 μM for KDM4A and 9
MOA study showed P7C3 could bind nicotinamide phosphoribosyltransferase (NAMPT)
(2015) Chem Biol
185(1):634-41
290(22):13641-53
EPZ-5676 - DOT1L inhibitor. CAS# 1380288-87-8 60160 4 μM for KDM4A andEPZ 5676, CAS No. 1380288 87 8, is a highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S adenosylmethionine. It inhibits proliferation of MLL AF4 rearranged cell line MV4 11 with an IC50 of 9 nM. It reduces H3K79 dimethylation with a cellular IC50 of 2. 6 nM in MV4 11 cells. EPZ 5676 has over 10, 000 fold selectivity against other HMTs. Its superior potency is
US$ 124.00
US$ 155.95
US$ 17.81
US$ 151.14
US$ 121.47
US$ 33.00
US$ 3026.50
US$ 52.00