CDK4/6-IN-2 indalone NS-398 is a non-steroidal an-inflammatory

NS-398 is a non-steroidal an-inflammatory agent

1-6H3/t12-

Lazabemide (250 nM) results in a clear inhibition of DOPAC formation

InChi: InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8

InChi: InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7

CDK4/6-IN-2 indalone NS-398 is a non-steroidal an-inflammatoryCDK4 6 IN 2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2. 7 and 16 nM for CDK4 and CDK6, respectively. Product information CAS Number: 1800506 48 2 Molecular Weight: 506. 59 Formula: C27H32F2N8 Chemical Name: 5 [(4 ethylpiperazin 1 yl)methyl] N {5 fluoro 4 [4 fluoro 2 methyl 1 (propan 2 yl) 1H 1,3 benzodiazol 6 yl]pyridin 2 yl}pyrimidin 2 amine Smiles: