HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S Water up to 50 mM

Water up to 50 mM

3(2H)-dione

Amatangelo MD

Smiles: CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N

BMS-708163 was used at 1-10 µM in vitro

HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S Water up to 50 mMHIF C2, CAS No. 1422955 31 4, is a potent and selective allosteric inhibitor of hypoxia inducible factor 2 (HIF 2). It binds within the internal cavity of HIF 2 PAS B (Kd of 81 nM) and disrupts heterodimerization of the full length HIF 2 transcription factor. HIF C2 functions effectively as a HIF 2 inhibitor in living cells, disrupting HIF 2 DNA binding and inhibiting the transcription of its target genes. Moreover, HIF C2 is selective for the HIF 2