Pay in 4 interest-free payments of $9.75 Learn more
Ships within 48 hours · Estimated delivery Jul 26 - Jul 31
CN1CCN(CCC1)C1N=C2C=C(OC)C(=CC2=C(NC2CCN(CC3C=CC=CC=3)CC2)N=1)OC
Compound 401 is a potent inhibitor of DNA-PK (IC50=0
Curr Hematol Malig Rep
PubMed PMID: 25865964
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity
CC-115 - CAS# 1228013-15-7 Catalog No.:M6483-10 CN1CCN(CCC1)C1N=C2C=C(OC)C(=CC2=C(NC2CCN(CC3C=CC=CC=3)CC2)N=1)OCCC 115, CAS No. 1228013 15 7, is a dual inhibitor of DNA dependent protein kinase (DNA PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC 115 binds to and inhibits the activity of DNA PK and both raptor mTOR (TOR complex 1 or TORC1) and rictor mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA PK and TOR. DNA PK, a serine threonine kinase and a
US$ 54.95
US$ 170.00
US$ 106.47
US$ 124.42
US$ 1872.08
US$ 120.40
US$ 501.48
US$ 139.10