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but activates only the α7 to any significant extent
10(5):481-2
is a novel potent and selective BMI-1 inhibitor
2017 Feb 14
2016 May 19
AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 but activates only the α7AZD6244, CAS No. 606143 52 6, (Selumetinib, ARRY 142886) is an orally active, highly potent and selective non ATP competitive MEK inhibitor, inhibiting MEK1 with an IC50 of 14 nM. In vitro cell viability inhibition screening of a tumor cell line panel found that cell lines harboring BRAF or RAS mutations were more likely to be sensitive to AZD6244. Treatment of primary HCC cells with AZD6244 led to growth inhibition, caspase 3 and caspase 7
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