You cannot target him save by discarding an enchantment, instant or sorcery, so that's card advantage
A Tale for the Ages brings a good reason to play auras, and in EDH decks that care about auras or enchantments, you should give this one a try
She could keep the board clear, could generate card advantage and a win condition, and she required an answer since her ultimate was basically game winning (although I have seen someone lose after using it)
He runs out of cards, forcing him to sacrifice the Solitary Confinement
For example, if youre building a deck around Urza, Lord High Artificer, you probably want a ton of cheap artifact creatures you can tap for mana, and then big heavy hitters you can cast with his second ability and all of that mana you generate