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Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases
Smiles: O=C1C2=CC=CC=C2[C@]2(C3C=CC(Cl)=CC=3)N1CCN2C(=O)C1=CC(F)=C(F)C=C1
3389/fimmu
shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ
Formula: C18H11Cl2NO4
MS645 1378 Interference of Paraben Compounds withMS645 is a bivalent BET bromodomains (BrD) inhibitor with a Ki of 18. 4 nM for BRD4 BD1 BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid tumor cells. Product information CAS Number: 2250091 96 2 Molecular Weight: 938. 04 Formula: C48H54Cl2N10O2S2 Chemical Name: 2 [(9S) 7 (4 chlorophenyl) 4,5,13 trimethyl 3 thia 1,8,11,12 tetraazatricyclo[8. 3. 0. 0,]trideca
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