GDC-0077 - CAS# 2060571-02-8 Catalog No.:M17007-C Smiles: CN(C)C1CCN(CC1)C1=CC(OC)=C(C=C1)NC1=NC(NC2=CC=CC=C2P(C)(C)=O)=C(Cl)C=N1

Smiles: CN(C)C1CCN(CC1)C1=CC(OC)=C(C=C1)NC1=NC(NC2=CC=CC=C2P(C)(C)=O)=C(Cl)C=N1

Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition

Formula: C42H56F2N8O6

It was developed by Pfizer for the treatment of obesity

Chemical Name: 1-[2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl]-3-(2-methylquinolin-4-yl)urea

GDC-0077 - CAS# 2060571-02-8 Catalog No.:M17007-C Smiles: CN(C)C1CCN(CC1)C1=CC(OC)=C(C=C1)NC1=NC(NC2=CC=CC=C2P(C)(C)=O)=C(Cl)C=N1GDC 0077 (RG6114) is a potent selective inhibitor of PI3K alpha (PI3K) with an IC50 of 0. 038 nM. GDC 0077 is >300 fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000 fold more selective over PIK family members. GDC 0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3. Product information CAS Number: 2060571 02 8 Molecular Weight: 407. 37 Formula: