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G-749 potently inhibits autophosphorylation of FLT3 with IC50 of ≤8 nM
2013 Nov 16
Bushnell T
37 mg/kg/day
Richards FM
TBK1/IKKε-IN-1(compound 1) Catalog No.:M7456-2 G-749 potently inhibits autophosphorylation ofTBK1 IKK IN 1 (compound 1) is a dual inhibitor of TANK binding kinase 1 (TBK1) and IB kinase (IKK IKK i) with IC50 of 1. 0 nM and 5. 6 nM for TBK1 and IKK, respectively. TBK1 IKK inhibition enhances response to PD 1 blockade, which effectively predicts tumor response in vivo. Product information CAS Number: 1893397 65 3 Molecular Weight: 513. 59 Formula: C28H31N7O3 Chemical Name: 5 (4 ((4 (4 (oxetan 3 yl)piperazin 1 yl)phenyl)amino) 1,3,5 triazin 2
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