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Smiles: NC1=NC=NC2=C1C(COC1C=C(Cl)C=CC=1)=NN2C1CCOCC1
resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB
Jacobson E
Epub 2017 Dec 28
(2009) J Med Chem
Danusertib (PHA-739358) Catalog No.:M7725-10 Smiles: NC1=NC=NC2=C1C(COC1C=C(Cl)C=CC=1)=NN2C1CCOCC1Danusertib, also known as PHA 739358, is a small molecule 3 aminopyrazole derivative with potential antineoplastic activity. Aurora kinase inhibitor PHA 739358 binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. This agent may preferentially bind to and inhibit Aurora B kinase. Aurora kinases, a family of serine threonine kinases, are important
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