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RO1138452 and RO3244794: characterization of structurally distinct
InChi: InChI=1S/C18H19N3O2S/c1-9-6-11(7-10(2)15(9)22)16-19-17(23)14-12-4-5-21(3)8-13(12)24-18(14)20-16/h6-7
InChiKey: WCAATDGMINWXPJ-BTJKTKAUSA-N
Vazquez JA
Chemical Name: 2-Chloro-4-[(1R
ON-01910 selective p38α PROTAC RO1138452 and RO3244794: characterization ofON 01910 is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo like kinase 1 inhibitor ON 01910. Na inhibits polo like kinase1 (Plk1), inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents.
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