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114(16):3439-47
Br J Pharmacol
71(15):5057-61
InChi: InChI=1S/C23H33N5O2/c1-2-14-27-15-17-28(18-16-27)20-8-6-19(7-9-20)21(29)26-23(10-4-3-5-11-23)22(30)25-13-12-24/h6-9H
4-tetrahydroquinazolin-6-yl)benzenesulfonamide
HCI-2509 (SP2509) - Reversible LSD1 Inhibitor. CAS# 1423715-09-6 054 114(16):3439-47HCI 2509 (also named as SP2509 or LSD1 C12) , CAS No. 1423715 09 6, is a highly potent, specific, and reversible Lysine Specific Demethylase 1 (LSD1) inhibitor. It inhibits LSD1 in biochemical assay with an IC50 ~13 nM, and has no activity against monoamine oxidase proteins MAO A and MAO B (>300 M). HCI 2509 is a non competitive inhibitor to bind LSD1, changes its solution dynamics in a manner distinct from TCP. It has minimal inhibition of CYPs and
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