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SB-267268 (60 mg/kg
and TNF-α is introduced as a positive control for NF-κB activation
71 L/kg) and a low systemic clearance (31
ADX47273 increased extracellular signal-regulated kinase and cAMP-responsive element-binding protein phosphorylation in hippocampus and prefrontal cortex
Epub 2018 Nov 13
Cilofexor mol hemisulfate SB-267268 (60 mg/kgCilofexor (GS 9674) is a potent, selective and orally active nonsteroidal FXR agonist with an EC50 of 43 nM. Cilofexor has anti inflammatory and antifibrotic effects. Cilofexor has the potential for primary sclerosing cholangitis (PSC) and nonalcoholic steatohepatitis (NASH) research. Product information CAS Number: 1418274 28 8 Molecular Weight: 586. 85 Formula: C28H22Cl3N3O5 Chemical Name: 2 [3 (2 chloro 4 {[5 cyclopropyl 3 (2,6 dichlorophenyl) 1,2
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