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It can also inhibit TGFβ–mediated Smad2 activation and hematopoietic suppression in primary hematopoietic stem cells in a dose-dependent manner
GSK 3117391
InChi: InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9
1-2H3/i1D3
115(3):631-6
CB-839 H 298 It can also inhibit TGFβ–mediatedTelaglenastat, also known as CB 839, an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Telaglenastat selectively and irreversibly inhibits glutaminase. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the
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