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InChiKey: AUFUWRKPQLGTGF-FMKGYKFTSA-N
Chemical Name: 11-hydroxy-8-methoxy-4-methyl-10-{[(2S
5-tetrahydro-1H-1-benzazepin-3-yl acetate
InChi: InChI=1S/C26H24N6O3/c1-3-32-24(28-29-30-32)20-9-6-5-8-19(20)18-14-12-17(13-15-18)16-31-23-21(25(33)34)10-7-11-22(23)27-26(31)35-4-2/h5-15H
13'-tetramethyl-10'-oxo-5'-oxaspiro[oxane-2
GNE-616 emsirolimus InChiKey: AUFUWRKPQLGTGF-FMKGYKFTSA-NGNE 616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1. 7 inhibitor (Ki of 0. 79 nM and Kd of 0. 38 nM for hNav1. 7) for the treatment of chronic pain. GNE 616 shows >1000 nM Kd and >2500 fold selectivity over hNav1. 1, hNav1. 3, hNav1. 4, and hNav1. 5. Selectivity over hNav1. 2 and hNav1. 6 is more modest at 31 and 73 fold, respectively. Product information CAS Number: 2349371 81 7 Molecular Weight: 537. 53
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