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specific and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor with an IC50 of 1
Epub 2013 Aug 2
24)12-13-5-6-16(26-2)19(9-13)29-30(20
InChi: InChI=1S/C23H21N3O2/c1-3-8-16(9-4-1)19-20-22(24-14-18-12-7-13-27-18)25-15-26-23(20)28-21(19)17-10-5-2-6-11-17/h1-6
Chemical Name: (6S)-6-hydroxy-3-[(1E
Cenobamate (YKP3089) Size:Contact [email protected] for quotation specific and covalent EZH2 (EnhancerCenobamate, a sodium channel blocker, enhances GABAergic transmission and has the potential to be a versatile CNS drug. Cenobamate (YKP3089) protects against MES induced seizures in mice with an ED50 of 9. 8 mg kg i. p., and in rats with an ED50 of 1. 9 mg kg p. o. In the sc Met seizures model, Cenobamate given ip inhibited the clonic seizures in mice and rats, with ED50 values of 28. 5 and 13. 6 mg kg, respectively. Cenobamate is also effective