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30)/t17-/m1/s1
Smiles: O=C1N=C(NC(=O)C2C=CC(Cl)=CC=2)SN1CC1C=CC(Cl)=CC=1
It accelerated FRAP recovery at 1 µM and no significant cytotoxicity up to 50 μM in U2OS cells
InChi: InChI=1S/C19H15Cl2NO3/c20-13-7-8-14(21)17-16(13)19(25
1418013-75-8
BSJ-03-123 rescein Diacetate 30)/t17-/m1/s1BSJ 03 123 is a Selective Cdk6 degrader. BSJ 03 123 exploits protein interface determinants to achieve proteome wide selectivity for the degradation of cyclin dependent kinase 6 (CDK6). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.
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