AG-1478 Size:Solid 10 mg Smiles: CC1=CC(=CC=C1C1C=CC(=CC=1)S(C)(=O)=O)OCC1=NN=C(SC2CCCC2)N1C1=CN=CC=C1

Smiles: CC1=CC(=CC=C1C1C=CC(=CC=1)S(C)(=O)=O)OCC1=NN=C(SC2CCCC2)N1C1=CN=CC=C1

desirable for a high number of disease targets

also known as PaTrin-2

2001 Jan 23

is a potent inhibitor of Wnt/β-catenin signaling

AG-1478 Size:Solid 10 mg Smiles: CC1=CC(=CC=C1C1C=CC(=CC=1)S(C)(=O)=O)OCC1=NN=C(SC2CCCC2)N1C1=CN=CC=C1Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTK. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor receptor (EGFR) kinase and block EGFR dependent cell proliferation. AG 1478 is an inhibitor of EGFR kinase with an IC50 value of 3 nM. 1 Due to its potency and selectivity,