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InChiKey: JIMHYXZZCWVCMI-ZSOIEALJSA-N
Blockade of mutant IDH1 impaired the growth of IDH1-mutant—but not IDH1-wild-type—glioma cells without appreciable changes in genome-wide DNA methylation
Formula: C22H20N4OS2
These sleep effects are also consistent with the pharmacokinetic profile of lorediplon
mean tumor numbers
ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 0281 InChiKey: JIMHYXZZCWVCMI-ZSOIEALJSA-NITD 1, CAS No. 1099644 42 4, is a novel and highly selective TGF pathway inhibitor identified by a high throughput, embryonic stem cell (ESC) cardiac differentiation screening. ITD 1 promoted cardiomyocyte differentiation specifically via degradation of the TGF type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC50 0. 40. 8 M), revealing a role for TGF signaling
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