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It can inhibit oncogenic RAS signaling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS
GNF-2 interfered with actin cytoskeletal organization and subsequently blocked the bone-resorbing activity of mature osteoclasts
PubMed Central PMCID: PMC4613137
ISRIB-treated mice display significant enhancement in spatial and fear-associated learning
Smiles: NC1=CC=CN=C1/C=N/NC(N)=S
KB-R7943 - CAS# 182004-65-5 60131 It can inhibit oncogenic RASKB R7943, CAS No. 182004 65 5, is a potent, selective inhibitor of the reverse mode of the Na+ Ca2+ exchanger (IC50 = 0. 7 M). KB R7943 does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. KB R7943 blocks opening of the mitochondrial permeability transition pore. KB R7943 restores endothelium dependent relaxation induced by advanced glycosylation end products in rat aorta. KB R7943 inhibits high glucose induced
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